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The U.S. Department of Transportation defines hazardous material as any material or substance that, due to its chemical properties, has the potential to cause injury, loss of life, or damage to property or the environment when transported in commerce. This includes materials that are radioactive, explosive, toxic, flammable, infectious, chemically reactive, or corrosive. In the U.S., the DOT regulates the shipping and packaging of hazardous materials being transported between states and also internationally.